BSE -- Bovine Spongiform Encephalopathy
("Mad Cow Disease")

Bovine spongiform encephalopathy (BSE) is a fatal brain disease of cattle. The disease is believed to be caused by a "self-replicating" protein (a prion) rather than a bacterium or virus. Meat and milk have not been shown to carry the infective agent and measures have been taken to exclude those parts shown to carry the infective agent (primarily brain and nervous tissue) from the food supply.Mad cow disease leaves spongy holes in the brain and is thought to be caused by a protein-gone-bad known as a prion. The latest test revealed that the prion in mad cow disease matches the one in humans with the new strain of CJD.

Prions - The Disease Causing Agent

 The disease appears to be caused by an unconventional infectious agent, originally described as a "slow virus," a "self-replicating protein" and more recently as a "prion," an aberrant conformation of normal protein (PrP). This agent is extremely resistant to heat and to normal sterilization processes. It does not evoke a detectable immune response or inflammatory reaction in host animals.

The prion protein, PrP, is a normal cell protein present on nerve cell membranes. The gene for PrP is present in most mammals. However, its normal function is unclear; mice without the protein appear to be fine.

The sequence of amino acids in PrP and PrPsc is identical. This means PrPsc is changed after synthesis from the gene. The change is in conformation or shape. PrP changes conformation, from predominantly helix to predominantly pleated sheet, creating PrPsc.

The altered PrPsc protein is catalytic or "self-propagating". One PrPsc causes other PrP molecules to change into PrPsc. The PrPsc protein is very resistant to endogenous protease that would normally destroy the protein. Because the PrPsc can't be broken down, it builds up, aggregates, then precipitates forming plaques and causing spongiform damage.

For the same reason that cells can not destroy PrPsc , prions are very heat resistant. While some loss of infectivity occurs at temperatures above 100°C, 30 to 60 minutes at more than 130°C is needed for inactivation. Prions remain infective after: sterilizing levels of radiation, formalin, extremes of pH, non-polar organic solvents, burying for years, passing through 0.1 µm filters (2.2 µm filters remove bacteria). Prions infectivity is destroyed by: 1M NaOH @ 55°C , chlorine bleach @ 20,000 ppm (household bleach is 50,000 ppm) hypochlorite.

What causes the original change in conformation of normal PrP to disease causing PrPsc? While the spontaneous conversion of PrP to PrPsc is unfavorable (corresponding to a low incidence of sporadic CJD), mutations in the PrP gene can make the spontaneous conversion more likely. There are at least 20 known mutations in the PrP gene sequence resulting in "spontaneous" PrPsc formation. Each mutation results in a slightly different conformation, and slightly different pathology. This results in different prion "strains". Regardless of the mutation the "spontaneous" PrPsc can also change non-mutated PrP into PrPsc.

 Creutzfeldt-Jakob disease (CJD) is a related prion diseases in humans. Almost all cases of CJD are spontaneous, inherited or iatrogenic. A small number of variant CJD cases have been linked to BSE exposure. Stanley B. Prusiner, University of California was recently awarded A Nobel Prize for his work on prions.

BSE, a transmissible spongiform encephalopathy (TSE) of cattle, was first observed in Great Britain in April, 1985, and was specifically diagnosed in 1986. By June, 1990, there were some 14,000 confirmed cases out of an estimated population of 10 million cattle in Great Britain.

The gross findings in kuru are minimal, and consist of congestion of blood vessels, which can be seen on this slide, and in long standing cases, cortical atrophy (not prominent in this case).

Another characteristic finding of kuru is shown on this slide: brush-like plaques, which are also called spikeballs and found in the cerebellum.

 

Bible Code Matrix 

This Code array shows the Hebrew of the Torah text from Genesis Chapter 143:15 and ends at Genesis Chapter 50:17

Central Term : PRION (  ELS  -447 )

Cluster-Report A

Cluster Matrix A

key words set :

Prion   ,   Protein  ,  Brain ,  Nerv ,   Atrophy "Degeneratin" Evil Disease

 Disease ,  Morbos  , Cattle , Cow  ,Cows , BSE   ,BSE  BSE  ,  Flesh ,    Therapy  , Vaccinate  , Creutzfeldt-Jakob(CJD)

the evil"Disease" in or of the Cattle -Transmissible

 

 

CODE ANALYSE

The words encoded many times at low or minimal intervals ; and have the exact same interval. 
 -Some of the key words have and sharing a common letter and share some common space.

***an important and significant point is that  in close proximity to the encoded word Prion we fuond the word Protein & Brain

Words with a Common Letters
the evil "Disease" in or of the Cattle -Transmissible

Prion          Protein

  • the words "transmissible" , "Disease" &" Cattle"they  have in common the letters:              He ,   Bet ,  Resh ,    Ayen  ,  He
  • Nearly the word Prion we fuond the words Protein ,Nerv & Brain

 

 

 

 
Prion        Disease         Flesh       Cow  Cow

Brain      Nerv    Nerv

The word  Prion shared with the word Brain the letter VAV

Cow  & Cow they have in common the letter Pe Ef

Verv & nerv shared with the letter Zadik

the word "Disease "Crossed the central term Prion & Cow

The word Brain crossed the central term Prion

 

 

The Evil "Disease" in the Cattle -Transmissible               Prion       Protein       Brain       Nerv  Nerv  Atrophy "Degeneration"

  • the words "transmissible" , "Disease" &" Cattle"they  have in common the letters:              He ,   Bet ,  Resh ,    Ayen  ,  He
  • The word Atrophy Crossed the word Prion & shared with it the letter Nun
  • The word Brain crossed the central term Prion
  • Nearly the word Prion we fuond the words Protein ,Nerv & Brain
  • The word Nerv crossed the word Nerv